Epidemic hemorrhagic
fever describes a collection of syndromes of acute febrile disease in which
shock and hemorrhage are the most obvious characteristics. Their
short incubation periods and mode of transmission have raised great concern
in the general public. While some viral hemorrhagic fevers or VHFs can
cause severe symptoms, other VHFs do not cause severe illness or death.
Viral hemorrhagic fevers are generally characterized by fever, muscle aches,
fatigue, weakness, and dizziness. More serious cases may involve
bleeding from body orifices, bleeding under the skin or bleeding in internal
organs. However, blood loss is rarely the cause of death in these
cases.
Secondary human
transmission rates are extremely high for VHFs, so universal precautions
are highly recommended for those caring for infected individuals.
Masks, gowns, and glove protection help to limit contact with contaminated
blood or tissue. Drawing of blood should be limited to prevent aerosolation
of the pathogen.
VHFs are caused by viruses of four distinct families: arenaviruses, filoviruses, bunyaviruses, and flaviviruses. Each of these families share a number of features:
-They are all RNA viruses, and all are covered, or enveloped, in a fatty
(lipid) coating.
-Their survival is dependent on an animal or insect host, called the natural
reservoir.
-The viruses are geographically restricted to the areas where their host
species live.
-Humans are not the natural reservoir for any of these viruses.
Humans are infected when they
come into contact with infected hosts. However, with some viruses, after
the accidental
transmission from the host, humans can transmit the virus to one another.
-Human cases or outbreaks of hemorrhagic fevers caused by these viruses
occur sporadically and
irregularly. The occurrence of outbreaks cannot be easily predicted.
-With a few noteworthy exceptions, there is no cure or established drug
treatment for VHFs.
Viral Hemorrhagic Families
References:
Centers for Disease
Control
World Health
Organization